Supreme Madness Part 1: Supreme had lost his powers but, with the power of the Hammer of Thor, he could defeat his arch-enemy, Grizlock. He is about to kill him when Grizlock offers him to give his powers back. 
In his laboratory, the mad scientist mades some experiences and finally fails. But the Supreme's psyché is tainted and he becomes mad. 
What happen when a powerful being like Supreme becomes mad. The answer in Supreme Madness Story-arc.